Major engineering works will see Cannon Street station shut this weekend.
All services will be replaced by buses between Deptford and Charlton. Buses replace trains at Deptford, Greenwich, Maze Hill and Westcombe Park.
On Sunday, Charing Cross, Waterloo East and London Bridge (with the exception of Hastings services) are also closed.
There are additional trains operating between New Cross and Dartford via Woolwich Arsenal and certain Hayes trains will run to and from New Cross.
There are no trains running between Lewisham and Hither Green - train tickets can be used on local bus routes 225 and 273 between Lewisham and Hither Green.
Trains will be diverted to run to and from Victoria, Blackfriars and New Cross.
Abbey Wood station will be closed on Sunday, with a bus replacement service operating when trains are not running, serving all stations from Plumstead to Dartford, including Abbey Wood.
Tickets can also be used on the Docklands Light Railway (DLR) between Lewisham and Greenwich.
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